Clinical UM Guideline
Subject: Cardiac Stress Testing with Electrocardiogram
Guideline #: CG-MED-57 Publish Date: 07/01/2026
Status: Reviewed Last Review Date: 05/14/2026
Description

This document addresses the indications for cardiac stress testing with electrocardiogram (EKG).

Note: For a high-level overview of this document, please see “Summary for Members and Families” below.

Clinical Indications

Medically Necessary:

Cardiac stress testing with electrocardiogram is considered medically necessary as part of a coronary evaluation for ANY of the following indications (A through G): 

  1. To diagnose obstructive coronary artery disease when either of the following are present (1 or 2):
    1. In adults with intermediate pretest probability of coronary artery disease on the basis of gender, age, and symptoms (see Table 1); or
    2. With vasospastic angina; or
       
  2. For risk assessment and prognosis in symptomatic individuals or those with a prior history of coronary artery disease who meet any of the following (1 through 5):
    1. As part of initial evaluation of individuals with suspected or known coronary artery disease; or
    2. In individuals previously evaluated with stress testing with suspected or known coronary artery disease, now with significant change in clinical status; or
    3. Individuals with low risk unstable angina 8 to 12 hours after presentation who have been free of active ischemic or heart failure symptoms; or
    4. Individuals with intermediate risk unstable angina 2 to 3 days after presentation who have been free of active ischemic or heart failure symptoms; or
    5. Individuals with intermediate risk unstable angina who have initial cardiac markers that are normal, a repeat electrocardiogram without significant change, and cardiac markers 6 to 12 hours after the onset of symptoms that are normal and no other evidence of ischemia; or
       
  3. Following a myocardial infarction for any of the following (1 through 4):
    1. Before discharge for prognostic assessment, activity prescription, and evaluation of medical therapy; or
    2. Early after discharge for prognostic assessment, activity prescription, evaluation of medical therapy, and cardiac rehabilitation if the pre-discharge exercise test was not done; or
    3. Late after discharge for prognostic assessment, activity prescription, evaluation of medical therapy, and cardiac rehabilitation if the early exercise test was submaximal (symptom limited; about 3 to 6 weeks); or
    4. After discharge for activity counseling and/or exercise training as part of cardiac rehabilitation following a coronary revascularization procedure; or
       
  4. With ventilatory gas analysis for any of the following (1, 2 or 3):
    1. Evaluation of exercise capacity and response to therapy in individuals with heart failure who are being considered for heart transplantation; or
    2. Assistance in the differentiation of cardiac versus pulmonary limitations as a cause of exercise-induced dyspnea or impaired exercise capacity; or
    3. Evaluation of exercise capacity when indicated for medical reasons in individuals in whom the estimates of exercise capacity from exercise test time or work rate are unreliable; or
       
  5. In valvular heart disease with chronic aortic regurgitation, aortic valve stenosis or mitral valve regurgitation, for any of the following (1, 2, or 3):
    1. For assessment of functional capacity and symptomatic responses when there is a history of equivocal symptoms; or
    2. For evaluation of symptoms and functional capacity before participation in athletic activities; or
    3. For prognostic assessment before aortic valve or mitral valve replacement in asymptomatic or minimally symptomatic individuals with left ventricular dysfunction; or
       
  6. Before and after a revascularization procedure for any of the following (1, 2, or 3):
    1. When there is demonstration of ischemia before revascularization; or
    2. For evaluation of recurrent symptoms that suggest ischemia after revascularization; or
    3. After discharge for activity counseling and/or exercise training as part of cardiac rehabilitation following coronary revascularization; or
       
  7. For evaluation of heart rhythm disorders for any of the following (1, 2, or 3):
    1. For programming of rate-adaptive pacemakers; or
    2. For evaluation of known or suspected exercise-induced arrhythmias; or
    3. For evaluation of medical, surgical, or ablative therapy in individuals with exercise-induced arrhythmias, including atrial fibrillation.

Not Medically Necessary:

Cardiac stress testing with electrocardiogram is considered not medically necessary when the criteria are not met and for all other applications including, but not limited to, screening in individuals with low risk pretest probability of disease and in the absence of symptoms suspicious for cardiovascular disease.

Summary for Members and Families

This document describes clinical studies and expert recommendations, and explains when cardiac stress tests with electrocardiogram (EKG or ECG) are clinically appropriate. The following summary does not replace the medical necessity criteria or other information in this document. The summary may not contain all of the relevant criteria or information. This summary is not medical advice. Please check with your healthcare provider for any advice about your health.

Key Information

A cardiac stress test with EKG, is a test that shows how the heart works during physical activity. It is also called an exercise EKG, treadmill test, graded exercise test, or stress EKG. The letters EKG stand for electrokardiogramm spelled in the German way because the test was invented in Germany. The test can also be called an ECG reflecting the English spelling of electrocardiogram. During a stress EKG, a person walks on a treadmill or pedals a bike while heart rate, blood pressure, and heart rhythm are checked. If a person cannot exercise, medicines may be used to make the heart work harder. This test helps doctors find blocked heart arteries, check heart rhythm problems, and see how well treatments are working. Like any test, it may lead to false alarms or more testing that is not actually needed.

What the Studies Show

Cardiac stress testing with EKG has been used for many years. It is a standard tool to check for blocked heart arteries, also called coronary artery disease. It can help doctors understand a person’s risk for future heart problems, especially for people who have symptoms such as chest pain or shortness of breath, or who already have heart disease. The test can also help guide exercise plans and heart rehabilitation after a heart attack or heart procedure.

National groups such as the American College of Cardiology (ACC) and the American Heart Association (AHA) have published guidance on when this test is helpful. The United States Preventive Services Task Force (USPSTF) recommends against using resting or exercise EKG to screen adults who have no symptoms and are at low risk for heart disease. This is because studies show it does not prevent heart attacks or death in this group. Unnecessary or unproven tests can lead to needless worry, or to more testing and treatment that does not help. For adults at higher risk who do not have symptoms, better studies are needed to know if screening with EKG improves health.

When is Cardiac Stress Testing with Electrocardiogram Clinically Appropriate?

Cardiac stress testing with electrocardiogram may be appropriate in these situations:

When is this not Clinically Appropriate?

Cardiac stress testing with EKG is not clinically appropriate when the criteria in this guideline are not met. It is also not appropriate for screening adults who have no symptoms and are at low risk for heart disease. Research reviewed by national experts found that screening in low-risk adults does not improve health outcomes.

(Return to Description)

Coding

The following codes for treatments and procedures applicable to this guideline are included below for informational purposes. Inclusion or exclusion of a procedure, diagnosis or device code(s) does not constitute or imply member coverage or provider reimbursement policy. Please refer to the member's contract benefits in effect at the time of service to determine coverage or non-coverage of these services as it applies to an individual member.

When services may be Medically Necessary when criteria are met:

CPT

 

93015

Cardiovascular stress test using maximal or submaximal treadmill or bicycle exercise, continuous electrocardiographic monitoring, and/or pharmacological stress; with supervision, interpretation and report

93016

Cardiovascular stress test using maximal or submaximal treadmill or bicycle exercise, continuous electrocardiographic monitoring, and/or pharmacological stress; supervision only, without interpretation and report

93017

Cardiovascular stress test using maximal or submaximal treadmill or bicycle exercise, continuous electrocardiographic monitoring, and/or pharmacological stress; tracing only, without interpretation and report

93018

Cardiovascular stress test using maximal or submaximal treadmill or bicycle exercise, continuous electrocardiographic monitoring, and/or pharmacological stress; interpretation and report only

 

 

ICD-10 Diagnosis

 

 

All diagnoses

When services are Not Medically Necessary:
For the procedure codes listed above when criteria are not met or for situations designated in the Clinical Indications section as not medically necessary.

Discussion/General Information

Summary

Cardiac stress testing, often involving electrocardiogram (EKG) monitoring during exercise or pharmacologic induction, is used to assess how the heart responds under stress. It is a standard practice for diagnosing coronary artery disease (CAD) and other cardiac conditions. Recommendations from various medical societies, including American College of Cardiology (ACC) and American Heart Association (AHA) generally support stress testing for symptomatic or high-risk individuals, while the United States Preventive Services Task Force (USPSTF) discourages EKG screening in asymptomatic adults at low risk and finds insufficient evidence to recommend for or against its use in intermediate- or high-risk asymptomatic adults. The tests are classified based on risk level according to clinical guidelines.

Discussion

Cardiac stress testing with EKG is a noninvasive diagnostic evaluation of the heart performed to assess suspected or known CAD. A cardiac stress test, also called a stress test, exercise EKG, treadmill test, graded exercise test, exercise electrocardiography, or stress EKG, is a test used to provide information about how the heart responds to exertion or induced stress. It usually involves walking on a treadmill or pedaling a stationary bike at increasing levels of difficulty, while cardiac parameters are monitored, including EKG, heart rate, and blood pressure. For individuals who are unable to tolerate exercise, pharmacologic stress testing can be performed where medications, such as dobutamine or adenosine, are injected to induce cardiac stress.

Cardiac stress testing with EKG is a well-established procedure that has been in widespread clinical use for many years and is considered the standard of care in the diagnosis and management of various cardiac conditions. The medically necessary criteria within this document are based on a review of the following evidence-based guidelines and specialty society guidance documents:

The following specialty society guidance documents were also reviewed in the development of this document:

The following tables assist in the assessment of risk and pretest probability of CAD:

Table 1: Pre-Test Probability of Coronary Artery Disease by Age, Gender and Symptoms*:

Age (yr)

Gender

Typical/Definite Angina Pectoris

Atypical/Probable Angina Pectoris

Non-Anginal Chest Pain

Asymptomatic

30-39

Men

Intermediate

Intermediate

Low

Very Low

 

Women

Intermediate

Very Low

Very Low

Very Low

40-49

Men

High

Intermediate

Intermediate

Low

 

Women

Intermediate

Low

Very Low

Very Low

50-59

Men

High

Intermediate

Intermediate

Low

 

Women

Intermediate

Intermediate

Low

Very Low

60-69

Men

High

Intermediate

Intermediate

Low

 

Women

High

Intermediate

Intermediate

Low

*Excerpted from the ACCF/SCAI/AATS/AHA/ASE/ASNC/HFSA/HRS/SCCM/SCCT/SCMR/STS appropriate use criteria for diagnostic catheterization (Patel, 2012) and the ACC/AHA 2002 guideline update for exercising testing (Gibbons, 2002).

Table 2: Classification of EKG Treadmill test results (performed without imaging)**:

Low risk EKG test result

Duke treadmill score > or = +5

Intermediate EKG risk treadmill test result

Duke treadmill score -10 to +4

High risk EKG treadmill test result

Duke treadmill score < = -11; OR

ST segment elevation; OR

Hypotension with exercise; OR

Ventricular tachycardia; OR

Prolonged ST segment depression

**Excerpted from the ACCF/SCAI/AATS/AHA/ASE/ASNC/HFSA/HRS/SCCM/SCCT/SCMR/STS appropriate use criteria for diagnostic catheterization (Patel, 2012).

Table 3: Classification of results of stress tests performed with imaging***:

 

SPECT MPI+ or Stress PET

Stress Echo

Low risk

<5% ischemic myocardium

No stress induced WMA++

Intermediate risk

5-10% ischemic myocardium

Stress induced WMA in a single segment

High risk

>10% ischemic myocardium

Stress-induced WMA in > or =2 segment; OR

Transient ischemic LV dilation; OR

Significant induced LV dysfunction.

+MPI = myocardial perfusion imaging; ++WMA = wall motion abnormality
***Excerpted from American College of Cardiology/American Heart Association (ACC/AHA) guidelines for coronary angiography (Scanlon, 1999).

The USPSTF (2016) does not recommend the use of resting or exercise EKG in asymptomatic adults at low risk of cardiovascular disease (Grade D). For asymptomatic adults at intermediate or high risk for cardiovascular disease, the USPSTF found insufficient evidence and made no recommendations for the use/non-use of resting or exercise EKG (Grade I). In 2018, the USPSTF issued another evidence report and systematic review: Screening for Cardiovascular Disease Risk with Resting or Exercise Electrocardiography with the following recommendations:

The USPSTF recommends against screening with resting or exercise electrocardiography (ECG) to prevent cardiovascular disease (CVD) events in asymptomatic adults at low risk of CVD events. (Grade D*)

The USPSTF concludes that the current evidence is insufficient to assess the balance of benefits and harms of screening with resting or exercise ECG to prevent CVD events in asymptomatic adults at intermediate or high risk of CVD events (Grade I**) (Jonas, 2018).

USPSTF Grading System:

Grade A: The USPSTF recommends the service. There is high certainty that the net benefit is substantial.
Suggestions for practice: Offer or provide this service.

Grade B: The USPSTF recommends the service. There is high certainty that the net benefit is moderate, or that there is moderate certainty that the net benefit is moderate to substantial.
Suggestions for practice: Offer or provide this service.

Grade C: The USPSTF recommends selectively offering or providing this service to individual patients based on professional judgment and patient preferences. There is at least moderate certainty that the net benefit is small.
Suggestions for practice: Offer or provide this service for selected patients depending on individual circumstances.

*Grade D: The USPSTF recommends against the service. There is moderate or high certainty that the service has no net benefit or that the harms outweigh the benefits.
Suggestions for practice: Discourage use of this service.

**Grade I: The USPSTF concludes that the current evidence is insufficient to assess the balance of benefits and harms of the service. Evidence is lacking, of poor quality, or conflicting, and the balance of benefits and harms cannot be determined.
Suggestions for practice: Read the clinical considerations section of USPSTF Recommendation Statement. If the service is offered, patients should understand the uncertainty about the balance of benefits and harms.

In 2005, an AHA scientific statement was issued regarding Exercise Testing in Asymptomatic Adults which provided the following conclusions:

Although current data suggest that in patients who have an estimated intermediate risk of developing disease, there may be value in additional noninvasive screening tests, including exercise testing, we agree with the recent recommendations of the US Preventive Services Task Force that there is insufficient evidence at this time to recommend exercise testing as a routine screening modality in asymptomatic adults. Although non-electrocardiographic measures, including functional capacity, chronotropic response, HR recovery, and ventricular ectopy, have been shown to predict adverse events in asymptomatic subjects, and although exercise testing measures have been shown to improve the prediction of coronary heart disease events over and above the Framingham Risk Score, there is no evidence that gaining this knowledge improves outcomes (Lauer, 2005).

The 2025 European Society of Cardiology (ESC)/European Association for Cardio-Thoracic Surgery (EACTS) guideline for Management of Valvular Heart Disease (Praz, 2026) emphasizes exercise testing as a useful adjunct in the evaluation of valvular heart disease, particularly in individuals with severe disease who report no or equivocal symptoms. Exercise testing may help unmask symptoms, clarify functional capacity, and refine risk stratification, thereby informing the timing of intervention. However, its role is selective and guided by clinical context, as testing is primarily recommended when symptom status is uncertain rather than for routine use.

The guideline for the Management of Adults with Congenital Heart Disease was updated in 2025 by the ACC and AHA (Gurvitz, 2025). The updated guideline does not introduce major new indications for stress EKG testing itself but reinforces its role within a broader functional and risk assessment framework. Exercise testing, preferably cardiopulmonary exercise testing (CPET), is recommended for objective evaluation of functional capacity, symptom clarification, and risk stratification, particularly when symptoms are unclear or discordant with resting findings. The guideline shifts away from routine or standalone use of basic exercise EKG toward integrated assessment (including imaging or CPET when appropriate) and supports its use to guide management decisions, monitor disease progression, and inform timing of intervention rather than as a primary diagnostic test in isolation.

Definitions

Angina pectoris: This term refers to chest pain or discomfort that is typically characterized by the presence of ALL three of the following:

  1. Centrally located or substernal; and
  2. Provoked by exertion or emotional stress; and
  3. Relieved by rest or nitroglycerin. Chest pain with all three characteristics is considered Definite or typical angina.

Grading of Angina Pectoris by the Canadian Cardiovascular Society Classification System:

Class I:

Ordinary physical activity does not cause angina, such as walking, climbing stairs. Angina (occurs) with strenuous, rapid, or prolonged exertion at work or recreation.

Class II:

Slight limitation of ordinary activity. Angina occurs on walking or climbing stairs rapidly, walking uphill, walking or stair climbing after meals or in cold, or in wind, or under emotional stress, or only during the few hours after awakening. Angina occurs on walking more than 2 blocks on the level and climbing more than one flight of ordinary stairs at a normal pace and in normal condition.

Class III:

Marked limitations of ordinary physical activity. Angina occurs on walking one to two blocks on the level and climbing one flight of stairs in normal conditions and at a normal pace.

Class IV:

Inability to carry on any physical activity without discomfort — anginal symptoms may be present at rest.

Cardiac catheterization: A general term describing the use of a thin catheter that is advanced into the bloodstream through an artery at the groin, arm or neck, followed by injection of a contrast agent (dye) that visualizes the coronary arteries and chambers of the heart. Cardiac catheterization, which can be done for diagnostic or therapeutic/interventional purposes or both, can be used to describe imaging of the coronary arteries, (also referred to as coronary angiography), or the heart chambers.

Cardiopulmonary exercise testing (CPET): An exercise test that combines standard electrocardiographic, hemodynamic, and symptom monitoring with breath-by-breath measurement of oxygen uptake (VO₂), carbon dioxide production (VCO₂), and minute ventilation through a face mask or mouthpiece. CPET provides comprehensive assessment of the cardiovascular, pulmonary, and skeletal muscle systems during graded exercise and allows quantification of peak aerobic capacity, ventilatory efficiency, and mechanisms of exercise limitation.

Chest pain (non-anginal): Chest pain or discomfort that meets one or none of the typical angina characteristics.

Congenital heart disease: A general term describing abnormalities in the structure of the heart that are present at birth. The abnormalities can include abnormal heart valves or abnormal communications between the different chambers of the heart.

Congestive heart failure (CHF) or heart failure: A condition in which the heart no longer adequately functions as a pump. As blood flow out of the heart slows, blood returning to the heart through the veins backs up, causing congestion in the lungs and other organs.

Coronary angiography: A cardiac catheterization procedure (see definition above) that is used to visualize the coronary arteries.

Coronary angioplasty: A therapeutic catheterization procedure that often follows the initial diagnostic imaging procedure. A small balloon placed at the site of the blockage in the coronary artery is inflated, in order to reopen the artery. Frequently a stent is also placed in the artery to maintain the opening. 

Guideline-directed medical therapy (GDMT): For context within this document, this terminology, which was formerly referred to as “Optimal medical therapy,” is defined as the use of at least 2 classes of medication to reduce angina symptoms (for example, beta blockers, calcium channel blockers, nitrate preparations, ranolazine). In the event that an individual is unable to tolerate 2 anti-angina medications, the maximum tolerated level of medical therapy will be considered to be GDMT.

Imaging procedure: This is a general term describing a technique to provide an image of a structure; in this case, a picture of the heart or coronary arteries. Angiography and right and left heart catheterization produce images by injecting dye into the heart chambers or coronary arteries, respectively. Other types of cardiac imaging procedures include echocardiography, CT or MRI scans.

Left heart: Describes the two chambers on the left side of the heart; the left atrium, which receives oxygenated blood from the lungs, and the left ventricle, which pumps the blood through the circulation.

Left ventricular ejection fraction (LVEF): The measurement of the heart's ability to pump blood through the body. Normal LVEF readings would be in the 58-70% range.

Myocardial infarction (MI): The medical term for heart attack. A heart attack occurs when the blood supply to part of the heart muscle (the myocardium) is severely reduced or blocked.

New York Heart Association (NYHA) definitions: The NYHA classification of heart failure is a 4-tier system that categorizes individuals based on subjective impression of the degree of functional compromise; the four NYHA functional classes are as follows:

Percutaneous coronary intervention (PCI): A general term describing a therapeutic procedure that is done at the same time as cardiac catheterization. The most common PCI is a coronary angioplasty with or without stent placement to treat the coronary artery disease identified in the immediately previous coronary angiography.

Pericardial tamponade: An acute condition where pressure builds up around the heart, impairing cardiac function, due to fluid accumulation in the pericardial sac, which is referred to as pericardial effusion.

Pericarditis (restrictive): Refers to inflammation of the pericardial sac, which is termed restrictive or constrictive when the inflammatory process results in diminished ability of the heart to beat normally. This condition is usually due to an infection but it may also occur following an MI or cardiac surgery.

Pulmonary hypertension: A rare lung condition where increased pressure in the pulmonary artery compromises cardiopulmonary function.

Right heart: Describes the two chambers on the right side of the heart; the right atrium, which receives the blood returning from the rest of the body, and the right ventricle that pumps this blood to the lungs.

Structural heart disease: A general term describing abnormalities in the structure of the heart, which includes diseases of the valves or congenital heart disease (present at birth). A cardiac catheterization procedure can evaluate the structure and function of the heart by assessing the left ventricular ejection fraction (see definition above), as well as the movement of the valves of the heart and of the chamber walls. 

Unstable angina: Angina that occurs at rest and is often referred to as crescendo angina, which is characterized by worsening or changing angina and is usually not relieved by nitroglycerin.

Valvular heart disease (VHD): Valvular heart disease is characterized by damage to, or a defect in, one of the four heart valves: the mitral, aortic, tricuspid or pulmonary. The severity of symptoms does not necessarily correlate with the severity of VHD which is defined in stages (See Table 4) based on valve anatomy, valve hemodynamics, severity of LV dilation and LV systolic function, as well as by the presence of symptoms. The symptoms are related to the underlying cause of the VHD, which may be aortic stenosis (blockage), aortic regurgitation (valve leakage), bicuspid aortic valve, mitral stenosis, mitral regurgitation, tricuspid stenosis, tricuspid regurgitation, pulmonic stenosis, and pulmonic regurgitation, but may include:

Vasculopathy: A term that refers to any disorder or disease process affecting the blood vessels.

Vasospastic angina: A painful condition in which spasms occur (usually at rest) in the arteries that supply blood to the heart.

References

Peer Reviewed Publications:

  1. Adabag AS, Grandits GA, Prineas RJ, et al. Relation of heart rate parameters during exercise test to sudden death and all-cause mortality in asymptomatic men. Am J Cardiol. 2008; 101(10):1437-1443.
  2. Turrini F, Scarlini S, Mannucci C, et al. Does coronary atherosclerosis deserve to be diagnosed early in diabetic patients? The DADDY-D trial. Screening diabetic patients for unknown coronary disease. Eur J Intern Med. 2015; 26(6):407-413.

Government Agency, Medical Society, and Other Authoritative Publications:

  1. Anderson JL, Adams CD, Antman EM, et al. 2012 ACCF/AHA focused update incorporated into the ACCF/AHA 2007 guidelines for the management of patients with unstable angina/non-ST-elevation myocardial infarction: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines. Circulation. 2013; 127(23):e663-e828.
  2. Bashore TM, Balter S, Barac A, et al. 2012 American College of Cardiology Foundation/Society for Cardiovascular Angiography and Interventions (ACCF/SCAI) expert consensus document on cardiac catheterization laboratory standards update. J Am Coll Cardiol. 2012; 59(24):2221-2305.
  3. Canadian Cardiovascular Society. Grading of angina pectoris. Available at: https://ccs.ca/wp-content/uploads/2020/12/Ang_Gui_1976.pdf. Accessed on March 11, 2026.
  4. Centers for Disease Control and Prevention (CDC). Million Hearts: strategies to reduce the prevalence of leading cardiovascular disease risk factors. United States, 2011. MMWR. 2011; 60(36):1248-1251.
  5. Chou R, Arora B, Dana T, et al. Screening asymptomatic adults for coronary heart disease with resting or exercise electrocardiography: systematic review to update the 2004 U.S. Preventive Services Task Force Recommendation [Internet]. Rockville (MD): Agency for Healthcare Research and Quality (AHRQ). 2011; Report No: 11-05158-EF-1.
  6. Chou R, Arora B, Dana T, et al. Screening asymptomatic adults with resting or exercise electrocardiography: a review of the evidence for the US Preventive Services Task Force. Ann Intern Med. 2011; 155(6):375-385.
  7. Costanzo M, Dipchand A, Starling R, et al. The International Society of Heart and Lung Transplantation guidelines for the care of heart transplant recipients. J Heart Lung Transplant. 2010; 29(8):914-956.
  8. Farmer SA, Lenzo J, Magid DJ, et al. Hospital-level variation in use of cardiovascular testing for adults with incident heart failure: findings from the Cardiovascular Research Network Heart Failure Study. JACC Cardiovasc Imaging. 2014; 7(7):690-700.
  9. Fihn SD, Gardin JM, Abrams J, et al. 2012 ACCF/AHA/ACP/AATS/PCNA/SCAI/STS guideline for the diagnosis and management of patients with stable ischemic heart disease: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines, and the American College of Physicians, American Association for Thoracic Surgery, Preventive Cardiovascular Nurses Association, Society for Cardiovascular Angiography and Interventions, and Society of Thoracic Surgeons. J Am Coll Cardiol. 2012; 60(24):e44-e164.
  10. Fletcher GF, Mills WC, Taylor WC. Update on exercise stress testing. Am Fam Physician. 2006; 74(10):1749-1754.
  11. Fowler-Brown A, Pignone M, Pletcher M, et al. Exercise tolerance testing to screen for coronary heart disease: a systematic review for the technical support for the U.S. Preventive Services Task Force. Ann Intern Med. 2004; 140(7):W9-W24.
  12. Gibbons RJ, Balady GJ, Bricker JT, et al. ACC/AHA 2002 guideline update for exercise testing: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Committee on Exercise Testing). 2002. J Am Coll Cardiol. 2002; 40(8):1531-1540.
  13. Goff DC Jr, Lloyd-Jones DM, Bennett G, et al. 2013 ACC/AHA Guideline on the assessment of cardiovascular risk: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines. Circulation. 2014; 129(25 Suppl 2):S49-S73.
  14. Gulati M, Levy PD, Mukherjee D, et al. 2021 AHA/ACC/ASE/CHEST/SAEM/SCCT/SCMR guideline for the evaluation and diagnosis of chest pain: a report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines. Circulation. 2021; 144(22):e368-e454.
  15. Gurvitz M, Krieger EV, Fuller S, et al. 2025 ACC/AHA/HRS/ISACHD/SCAI guideline for the management of adults with congenital heart disease: a report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines. J Am Coll Cardiol. 2026; 87(7):822-976.
  16. Heidenreich PA, Bozkurt B, Aguilar D, et al. 2022 AHA/ACC/HFSA guideline for the management of heart failure: a report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines. J Am Coll Cardiol. 2022; 79:e263-e421.
  17. Jonas DE, Reddy S, Cook Middleton J, et al. Screening for cardiovascular disease risk with resting or exercise electrocardiography: evidence report and systematic review for the US Preventive Services Task Force (USPSTF). JAMA. 2018; 319(22):2315-2328.
  18. Lauer M, Froelicher ES, Williams M, Kligfield P. American Heart Association scientific statement: exercise testing in asymptomatic adults: a statement for professionals from the American Heart Association Council on Clinical Cardiology, Subcommittee on Exercise, Cardiac Rehabilitation, and Prevention. Circulation. 2005; 112(5):771-776.
  19. Mieres JH, Gulati M, Bairey Merz N, et al. American Heart Association Cardiac Imaging Committee of the Council on Clinical Cardiology, Cardiovascular Imaging and Intervention Committee of the Council on Cardiovascular Radiology. Role of noninvasive testing in the clinical evaluation of women with suspected ischemic heart disease a Consensus Statement from the American Heart Association. Circulation. 2014; 130(4):350.
  20. Nishimura RA, Otto CM, Bonow RO, et al. 2014 AHA/ACC Guidelines for the management of patients with valvular heart disease: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines. J Am Coll Cardiol. 2014; 63(22):e57-185.
  21. O’Gara PT, Kushner FG, Ascheim DD, et al. 2013 ACCF/AHA guideline for the management of ST-elevation myocardial infarction: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines. Circulation. 2013; 127(4):e362-e425.
  22. Ommen SR, Ho CY, Asif IM, et al. 2024 AHA/ACC/AMSSM/HRS/PACES/SCMR guideline for the management of hypertrophic cardiomyopathy: a report of the American Heart Association/American College of Cardiology Joint Committee on Clinical Practice Guidelines. Circulation. 2024;149(23):e1239-e1311.
  23. Palaniappan L, Allen N, Almarzooq Z, et al. 2026 heart disease and stroke statistics: a report of US and global data from the American Heart Association. Circulation. 2026; 153(9):e275-e906.
  24. Patel MR, Bailey SR, Bonow RO, et al. ACCF/SCAI/AATS/AHA/ASE/ASNC/HFSA/HRS/SCCM/SCCT/SCMR/STS 2012 appropriate use criteria for diagnostic catheterization: American College of Cardiology Foundation Appropriate Use Criteria Task Force Society for Cardiovascular Angiography and Interventions American Association for Thoracic Surgery American Heart Association, American Society of Echocardiography American Society of Nuclear Cardiology Heart Failure Society of America Heart Rhythm Society, Society of Critical Care Medicine Society of Cardiovascular Computed Tomography Society for Cardiovascular Magnetic Resonance Society of Thoracic Surgeons. Catheter Cardiovasc Interv. 2012; 80(3):E50-E81.
  25. Pelliccia A, Sharma S, Gati S, et al. 2020 ESC Guidelines on sports cardiology and exercise in patients with cardiovascular disease. Eur Heart J. 2021; 42(1):17-96.
  26. Praz F, Borger MA, Lanz J, et al. 2025 ESC/EACTS guidelines for the management of valvular heart disease. Eur Heart J. 2025; 46(44):4635-4736.
  27. Scanlon PJ, Faxon DP, Audet AM, et al. ACC/AHA guidelines for coronary angiography. A report of the American College of Cardiology/American Heart Association Task Force on practice guidelines (Committee on Coronary Angiography). Developed in collaboration with the Society for Cardiac Angiography and Interventions. J Am Coll Cardiol. 1999; 33(6):1756-1824.
  28. U.S. Preventive Services Task Force (USPSTF). Cardiovascular disease risk: screening with electrocardiography. June 2018. Available at: https://www.uspreventiveservicestaskforce.org/uspstf/document/RecommendationStatementFinal/cardiovascular-disease-risk-screening-with-electrocardiography. Accessed on March 6, 2026.
  29. Warnes CA, Williams RG, Bashore TM, et al. ACC/AHA 2008 guidelines for the management of adults with congenital heart disease: executive summary: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (writing committee to develop guidelines for the management of adults with congenital heart disease). Circulation. 2008; 118(23):2395-2451.
  30. Williams SV, Fihn SD, Gibbons RJ; American College of Cardiology/American Heart Association/American College of Physicians-American Society of Internal Medicine. Guidelines for the management of patients with chronic stable angina: diagnosis and risk stratification. Ann Intern Med. 2001; 135(7):530-547.
  31. Wolk MJ, Bailey SR, Doherty JU, et al. ACCF/AHA/ASE/ASNC/HFSA/HRS/SCAI/SCCT/SCMR/STS 2013 multimodality appropriate use criteria for the detection and risk assessment of stable ischemic heart disease: a report of the American College of Cardiology Foundation Appropriate Use Criteria Task Force, American Heart Association, American Society of Echocardiography, American Society of Nuclear Cardiology, Heart Failure Society of America, Heart Rhythm Society, Society for Cardiovascular Angiography and Interventions, Society of Cardiovascular Computed Tomography, Society for Cardiovascular Magnetic Resonance, and Society of Thoracic Surgeons. J Am Coll Cardiol. 2014; 63(4):380-406.
  32. Wright RS, Anderson JL, Adams CD, et al. 2011 ACCF/AHA Focused update of the guidelines for the management of patients with unstable angina/non-ST-elevation myocardial infarction (updating the 2007 guideline): a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines. Circulation. 2011; 123(18):2022-2060.
  33. Yancy CW, Jessup M, Bozkurt B, et al. 2013 ACCF/AHA guidelines for the management of heart failure: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines. Circulation. 2013; 128(16):e240-e327.
Websites for Additional Information
  1. American Heart Association, American College of Cardiology. Pooled cohort equations cardiovascular risk estimator. Available at: http://tools.acc.org/ASCVD-Risk-Estimator-Plus/#!/calculate/estimate/. Accessed on March 6, 2026.
  2. National Heart, Lung and Blood Institute (NHLBI), National Institutes of Health (NIH). Heart tests. March 24, 2022. Available at: https://www.nhlbi.nih.gov/health/health-topics/topics/stress. Accessed on March 6, 2026.
Index

Exercise Stress test, Treadmill
Stress test, Cardiac
Stress test, Pharmacologic

History

Status

Date

Action

Reviewed

05/14/2026

Medical Policy & Technology Assessment Committee (MPTAC) review. Added “Summary for Members and Families section.” Revised Description, Discussion/General Information, Definitions, References, Websites for Additional Information, and Index sections.

Reviewed

05/08/2025

MPTAC review. Revised Description, References, and Website sections.

Revised

05/09/2024

MPTAC review. Revised MN criteria terminology. Updated Description, References and Website sections.

Reviewed

05/11/2023

MPTAC review. Updated References and Website sections.

Reviewed

05/12/2022

MPTAC review. References were updated.

Revised

05/13/2021

MPTAC review. Minor grammatical edit to Clinical Indications in valvular disease and before or after revascularization for clarification. Updated References section. Reformatted Coding section.

Reviewed

05/14/2020

MPTAC review. Updated References section.

Revised

06/06/2019

MPTAC review. Clarified terminology and removed acronym (ECG) in the Clinical Indications section. Updated References section.

Revised

07/26/2018

MPTAC review. Removed acronyms from Title and Clinical Indications section. Updated Description, Discussion and References sections.

 

05/03/2018

The document header wording updated from “Current Effective Date” to “Publish Date.”

New

08/03/2017

MPTAC review. Initial document development.

 


Federal and State law, as well as contract language, and Medical Policy take precedence over Clinical UM Guidelines. We reserve the right to review and update Clinical UM Guidelines periodically. Clinical guidelines approved by the Medical Policy & Technology Assessment Committee are available for general adoption by plans or lines of business for consistent review of the medical necessity of services related to the clinical guideline when the plan performs utilization review for the subject. Due to variances in utilization patterns, each plan may choose whether to adopt a particular Clinical UM Guideline. To determine if review is required for this Clinical UM Guideline, please contact the customer service number on the member's card.

Alternatively, commercial or FEP plans or lines of business which determine there is not a need to adopt the guideline to review services generally across all providers delivering services to Plan’s or line of business’s members may instead use the clinical guideline for provider education and/or to review the medical necessity of services for any provider who has been notified that his/her/its claims will be reviewed for medical necessity due to billing practices or claims that are not consistent with other providers, in terms of frequency or in some other manner.

No part of this publication may be reproduced, stored in a retrieval system or transmitted, in any form or by any means, electronic, mechanical, photocopying, or otherwise, without permission from the health plan.

© CPT Only - American Medical Association